ARA-290

ARA-290 in Canada is supplied by Horizon Peptides as a lyophilized powder in sealed 10 mg research vials, available singly or in 3-vial and 10-vial packs. ARA-290 is a synthetic erythropoietin-derived peptide studied in tissue-protection signalling research.

ARA-290, also catalogued as cibinetide, is an eleven-residue peptide derived from a region of erythropoietin. Erythropoietin is best known as the hormone governing red blood cell production, but the fragment reproduced here corresponds to a structurally distinct part of the molecule.

That distinction is the point. The described tissue-protective signalling attributed to erythropoietin is associated with a different receptor arrangement than its haematopoietic role, and a fragment that maps to one and not the other allows the two to be examined separately.

Separating two roles carried by one parent molecule is among the harder problems in this field, because any effect seen with the intact hormone could belong to either. A fragment that reaches only one of them turns an ambiguous result into a clean one.

Research using it concerns the innate repair receptor and tissue-protection pathways in animal and cell models, generally with the intact hormone as a comparison arm.