Melanotan2NasalSpray

Melanotan 2 nasal spray in Canada is supplied by Horizon Peptides as a pre-prepared 10 mg research spray bottle, available singly or in 3-bottle and 5-bottle packs. Melanotan 2 is a synthetic cyclic analogue of alpha-melanocyte-stimulating hormone studied in melanocortin receptor research.

Melanotan 2 is a cyclic peptide, Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH, with a molecular weight of 1025.2. The ring structure is the defining feature: closing the backbone into a ring constrains its shape and slows enzymatic breakdown compared with the linear hormone fragment it is modelled on.

Because it is shorter and more stable than natural alpha-MSH, it is widely used as a reference compound in melanocortin receptor binding studies, where a consistent, well-characterised analogue is more practical than the parent hormone.

Its stability relative to the natural hormone is the practical reason it appears so often in receptor work. A compound that persists through an assay gives cleaner comparative data than one degrading over the same period.