Tirzepatide

Tirzepatide in Canada is supplied by Horizon Peptides as a lyophilized powder in sealed research vials, stocked in 5 mg, 10 mg and 15 mg sizes with single-vial, 3-vial and 10-vial pack options. Tirzepatide is a synthetic dual-receptor peptide studied in metabolic signalling research.

Tirzepatide is a long synthetic sequence with a molecular weight of 4813.0, the heaviest metabolic peptide stocked here. It carries Aib residues, a non-standard amino acid introduced specifically to resist enzymatic cleavage at positions where natural sequences are cut first.

Its defining characteristic in the literature is acting at two receptor families rather than one, GLP-1 and GIP. Designing a single molecule to engage two related but distinct receptors is a harder problem than targeting either alone, and much of the research interest lies in how that dual engagement is achieved structurally.

Laboratory work using it concerns receptor binding ratios between the two families, and comparison against single-receptor sequences to establish what the second interaction contributes.